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US 9,547,004 B2Granted
Rapid quantification of biomolecules in a selectively functionalized nanofluidic biosensor and method thereof
AssigneeAbionic SA
InventorsNicolas Durand, Iwan Märki, Stéphane Broillet, Annick Mayor, Theo Lasser
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Abstract
A method and device for the rapid quantification of biomolecules (320) present in a nanochannel (210) is claimed. In particular, the present invention relates to a novel concept of liquid actuation and selectively functionalized surfaces in a nanochannel that create a concentration gradient of transitory immobilized biomolecules (340) across the nanochannel. The present concept enables the quantification of biomolecular interactions of interest (320).
Claims9
A biosensor for detecting and quantifying fluorescently-labeled biomolecules;
- said biosensor comprising a nanochannel defined between two substrates and containing one or more selectively functionalized areas on which are immobilized biomarkers, said nanochannel further defined by a lateral input aperture and a lateral output aperture, said input aperture is designed to allow a solution containing biomolecules to enter said nanochannel, and said output aperture contains or is in contact with a driving component that drives said solution through said nanochannel by capillarity.
Dependencies are inferred from the claim text.