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US 9,546,387 B2Granted
Microbial production of muconic acid and salicylic acid
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorsYajun Yan, Yuheng Lin
Life of this patent
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Abstract
The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
Claims10
A genetically engineered microorganism comprising a genetically engineered metabolic pathway for the production of muconic acid from a salicylic acid intermediate, said pathway comprising:
- a first module expressing a plurality of enzymes associated with the biosynthesis of salicylic acid, said plurality of enzymes comprising an isochorismate synthase (ICS) and an isochorismate pyruvate lyase (IPL);
- and
- a second module expressing a plurality of enzymes associated with the conversion of salicylic acid to muconic acid, said plurality of enzymes comprising a salicylate 1-monoxygenase (SMO) and a catechol 1,2-dioxygenase (CDO).
Dependencies are inferred from the claim text.