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US 9,545,772 B2Granted
Array structures of containers
AssigneeThe Johns Hopkins University
InventorsDavid H. Gracias, Yevgeniy Vladimirovich Kalinin, Christina Lee Randall
Life of this patent
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Abstract
An array structure includes a plurality of containers arranged in a predetermined pattern. Each container of the plurality of containers has a maximum outer dimension that is less than about 1 cm, and each container of the plurality of containers has a substantially predetermined porosity.
Claims21
An array structure comprising;
- a substrate having a surface with a plurality of recessed slots;
- and
- a plurality of containers arranged in a predetermined pattern with respect to each other in at least some of said recessed slots of said substrate, each of the plurality of containers having a spherical or polyhedral shape,
- wherein each container of said plurality of containers is attached to the substrate or to another container of said plurality of containers,
- wherein each container of said plurality of containers has an enclosing structure defining a plurality of pores and has a maximum outer dimension that is less than about 1 mm,
- wherein each container of said plurality of containers has a substantially predetermined porosity, and
- wherein at least one pore of said plurality of pores is facing a direction that is non-coplanar with a plane defined by directions of at least two other of said plurality of pores such that said substantially predetermined porosity is a three-dimensional porosity.
4 more elements
A bio-artificial pancreas, comprising:
- a substrate having a surface with a plurality of recessed slots;
- and
- a plurality of porous containers attached to said substrate in said recessed slots, each container of said plurality of porous containers having an enclosing structure defining a plurality of pores,
- wherein each of the plurality of porous containers has a spherical or polyhedral shape and a maximum outer dimension that is less than about 1 mm,
- wherein said plurality of porous containers are constructed to have a size, shape and porosity such that said plurality of porous containers are suitable to contain pancreatic islet cells therein, allow insulin produced by said pancreatic islet cells to pass therethrough, and provide immuno-isolation for said pancreatic islet cells, and
- wherein at least one pore of said plurality of pores is facing a direction that is non-coplanar with a plane defined by directions of at least two other of said plurality of pores such that said substantially predetermined porosity is a three-dimensional porosity.
3 more elements
A dynamic display device, comprising:
- a substrate having a surface with a plurality of recessed slots;
- and
- a plurality of containers attached to said substrate in a predetermined pattern in said recessed slots, each container of said plurality of containers having an enclosing structure defining a plurality of pores,
- wherein each of the plurality of porous containers has a spherical or polyhedral shape and a maximum outer dimension that is less than about 1 mm,
- wherein each container has a size, shape and porosity to allow a liquid to diffuse therefrom with a predetermined diffusion pattern as a function of time when said plurality of containers are immersed in a diffusion medium while in use, and
- wherein at least one pore of said plurality of pores is facing a direction that is non-coplanar with a plane defined by directions of at least two other of said plurality of pores such that said substantially predetermined porosity is a three-dimensional porosity.
3 more elements
Dependencies are inferred from the claim text.