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US 9,545,444 B2Granted
Anti-tumor T cell immunity induced by high dose radiation
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSamuel Strober, Alexander Filatenkov
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Abstract
Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual.
Claims21
A method for generating a population of T cells for treating cancer, the method comprising:
- subjecting an individual to a high dose of radiation at a tumor site;
- collecting a population of cells from the individual after a period of time sufficient for activation of T cells, wherein the collected population of cells comprises T cells and CD34+ cells;
- and
- purifying the T cells from the collected population of cells.
1 more element
Dependencies are inferred from the claim text.