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US 9,545,423 B2Granted
Tannin-chitosan composites
AssigneeWisconsin Alumni Research Foundation
InventorsJess Dreher Reed, Christian Gerald Krueger, Sergio Madrigal-Carballo
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AssigneeWisconsin Alumni Research Foundation
InventorsJess Dreher Reed, Christian Gerald Krueger, Sergio Madrigal-Carballo
Estimating the term…
The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
A composition comprising a matrix of chitosan and tannins, wherein the tannins comprise one or more oligomeric proanthocyanidins or oligomeric hydrolysable tannins, wherein the chitosan is electrostatically bonded to the one or more oligomeric proanthocyanidins or oligomeric hydrolysable tannins via hydrogen bonding, and wherein the matrix of chitosan and tannins is in the form of a chitosan-tannin composite material.
A composition comprising a matrix of chitosan and tannins, wherein the tannins comprise one or more oligomeric proanthocyanidins or oligomeric hydrolysable tannins, wherein the chitosan is electrostatically bonded to the one or more oligomeric proanthocyanidins or oligomeric hydrolysable tannins via hydrogen bonding, wherein the matrix of chitosan and tannins is in the form of a chitosan-tannin composite material, and wherein the composition is a bio-foam, or the composition forms a coating on the surface of a liposome.
A method of oral vaccination comprising orally administering a chitosan-tannin composite nanoparticle and an antigen, wherein the tannin composite nanoparticle comprises a matrix of chitosan and tannins, wherein the tannins comprise one or more oligomeric proanthocyanidins or oligomeric hydrolysable tannins, wherein the chitosan is electrostatically bonded to the one or more oligomeric proanthocyanidins or oligomeric hydrolysable tannins via hydrogen bonding.
Dependencies are inferred from the claim text.