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US 9,541,558 B2Granted
Cysteine hydrazide nicotinamide for glycomics and glycoproteomics uses
AssigneeCalifornia Institute of Technology
InventorsWilliam M. Clemons, Kyoung-Soon Jang, Roger Nani, Sergiy Levin, Sarah Reisman
Life of this patent
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Abstract
A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
Claims3
A compound having a structure of Formula (II):
- or a salt thereof, wherein:
- n is an integer from 1-10;
- R is a nitrogen-containing ring capable of forming a salt;
- wherein the nitrogen-containing ring is a ring selected from the group consisting of pyridyl, pyridazinyl, pyrazinyl, quinoxalyl, indolizinyl, quinazolinyl, purinyl, quinolinyl, pyrimidinyl, pyrrolyl, pyrazolyl, tetrazolyl, imidazolyl, triazolyl, indolyl, piperidinyl, piperazinyl, and pyrrolidinyl;
- and
- R1 is H or saccharide.
3 more elements
Dependencies are inferred from the claim text.