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US 9,541,548 B1Granted
Human biosensors for detecting ATP
OwnerAngela Huanginventor
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Abstract
This invention provides biosensors, cell models, and methods of their use for monitoring heme, oxygen or ATP. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.
Claims6
An ATP sensor peptide construct comprising:
- a binding domain which binds to ATP and comprises the amino acid sequence of SEQ ID NO:
- 18;
- a fluorescent reporter domain, wherein the fluorescent reporter is adapted to fluoresce at wavelengths in the range from 500 nm to 1400 nm;
- and
- wherein the fluorescent reporter domain is adapted to change fluorescent emissions characteristics in response to binding of the binding domain to ATP.
2 more elements
Dependencies are inferred from the claim text.