Fusion antibodies
AssigneeCatalent Pharma Solutions, LLC
InventorsGregory T. Bleck, Dona York, Ian Collins
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Abstract
The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.
Claims5
A composition comprising a multivalent antigen binding protein comprising at least two polypeptides, wherein each of said polypeptides comprises an antibody heavy chain comprising variable and Fc regions encoded by an antibody heavy chain gene from a parental antibody fused to an antibody light chain encoded by an antibody light chain gene from said parental antibody via a peptide linker so that said heavy and said light chain are expressed as a single polypeptide chain, wherein said antibody heavy chain has a C-terminus and said antibody light chain is fused at said C-terminus to said antibody heavy chain via said peptide linker, wherein said at least two polypeptides are joined via di-sulfide bonds.
A composition comprising a multivalent antigen binding protein comprising at least five polypeptides, wherein each of said polypeptides comprises an antibody heavy chain comprising variable and Fc regions encoded by an antibody heavy chain gene from a parental antibody fused to an antibody light chain encoded by an antibody light chain gene from said parental antibody via a peptide linker so that said heavy and said light chain are expressed as a single polypeptide chain, wherein said antibody heavy chain has a C-terminus and said antibody light chain is fused at said C-terminus to said antibody heavy chain via said peptide linker, wherein said at least five polypeptides are joined via di-sulfide bonds.
Dependencies are inferred from the claim text.