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US 9,541,546 B2Granted
Method of promoting excitatory synapse formation with an anti-Ephexin5 phospho-Y361 antibody
AssigneePresident and Fellows of Harvard College
InventorsJohn Salogiannis, Michael E. Greenberg, Seth S. Margolis
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Abstract
The invention provides methods of screening a compound that can increase spine/excitatory synapse formation and/or numbers. The compound is identified by contacting Ephexin5 with a test compound and selecting the compounds that inhibit Rho GEF activity of Ephexin5. Additionally, the invention also provides methods for increasing spine/excitatory synapse formation and/or numbers by contacting a neuron with an Ephexin5 inhibitor.
Claims6
A method of promoting spine/excitatory synapse formation, the method comprising:
- contacting a neuron with an anti-Ephexin5 antibody, wherein the anti-Ephexin5 antibody is anti-Ephexin5 phospho-Y361 (α-p361) antibody.
Dependencies are inferred from the claim text.