Method of selecting chemotherapeutic agents for an isolated organ or regional therapy
AssigneeDelcath Systems, Inc.
InventorsEamonn P. Hobbs, Daniel S. Johnston
Life of this patent
Estimating the term…
Abstract
A method for optimal selection of cytotoxic agents for organ or region specific therapy that includes extracorporeal filtration of the cytotoxic agent from blood drained from the organ or region being treated and return of the filtered blood to a mammal is disclosed.
Claims30
A method of identifying chemotherapeutic agents for use in a regional or an isolated organ treatment of a cancer in a mammal where the chemotherapeutic agent is filtered from blood and returned to the mammal, comprising:
- screening a panel of chemotherapeutic agents for effectiveness against the cancer;
- screening the panel of chemotherapeutic agents for toxicity in the organ to be treated;
- and
- identifying chemotherapeutic agents from the panel of chemotherapeutic agents that are capable of being filtered from blood at a rate of flow of from about 100 to about 1000 mL/minute.
A method of selecting chemotherapeutic agents for use in a regional or an isolated organ treatment of a cancer in a patient where blood is filtered to remove the chemotherapeutic agent before the blood is returned to the patient, comprising:
- screening a panel of chemotherapeutic agents for effectiveness against the cancer by establishing that it can kill cancer cells of the type of the cancer;
- screening the panel of chemotherapeutic agents for toxicity in the organ to be treated
- identifying chemotherapeutic agents that can be filtered from blood with an efficiency of at least about 70%;
- and
- selecting one or more of the chemotherapeutic agent that is effective against the cancer and capable of being filtered from blood with an efficiency of at least about 70% for use in the regional or the isolated organ treatment.
A method of optimizing selection of chemotherapeutic agents for use in an isolated region or isolated organ treatment of a cancer in a mammal where blood is filtered to remove the chemotherapeutic agent before the blood is returned to the mammal, comprising:
- identifying a chemotherapeutic agent effective at treating the cancer at high dose and short term exposure by testing through a dose range of 0 to 20 times the maximal tolerated system concentration;
- determining a filtration media that can adsorb the chemotherapeutic agent from blood at an efficiency of at least about 70% and at flow rates of about 100 to about 1000 mL/minute and does not substantially remove blood components;
- and
- establishing that the chemotherapeutic agent at effective doses for killing cancer is not toxic to the region or organ.
A method of optimizing selection of chemotherapeutic agents for use in an isolated region or isolated organ treatment of a cancer in a mammal where blood is filtered to remove the chemotherapeutic agent before the blood is returned to the mammal, comprising:
- identifying a chemotherapeutic agent effective at treating the cancer by determining effectiveness at killing cancer cell lines;
- determining a filtration media that can adsorb the chemotherapeutic agent from blood at an efficiency of at least about 70% and at flow rates of about 100 to about 1000 mL/minute and does not substantially remove blood components;
- and
- establishing that the chemotherapeutic agent at effective doses for killing cancer is not toxic to the region or organ.
A method of identifying chemotherapeutic agents for use in regional or isolated organ treatment of a cancer, comprising:
- identifying chemotherapeutic agents suitable for killing cancer cells of interest in a short term treatment of between 30 minutes and 60 minutes at doses that will not cause irreversible toxicity to a_region or an organ of the regional or isolated organ treatment;
- and
- developing a filtration system capable of filtering the chemotherapeutic agents at a filter efficiency of at least about 70% from whole blood or plasma at flow rates of between about 100 mL/minute to about 1000 mL/minute and does not substantially remove blood components.
Dependencies are inferred from the claim text.