Therapeutic use of activators of zinc finger protein GL13
AssigneeUniversitäT Leipzig
InventorRolf Gebhardt
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Abstract
The present invention relates to the therapeutic use of activators of the zinc finger protein GLI3 in diseases that are associated with reduced Hedgehog signaling in hepatocytes, in particular Polycystic ovary syndrome, Steatosis hepatis, Steatohepatitis and/or Adipositas. The invention further relates to methods of treating an individual with said activator, a pharmaceutical composition comprising said activator and the use of said activator as food supplement.
Claims9
A method for treating or preventing a disease associated with reduced Hedgehog signaling in hepatocytes, including the step of administering to an individual in need thereof a therapeutically effective amount of an activator of the Hedgehog signaling pathway selected from the group consisting of:
- Sonic hedgehog (Shh), Indian hedgehog (Ihh), Desert hedgehog (Dhh), Smoothened agonist (SAG);
- compounds according to the following formula (1)
- wherein X is selected from thiophenes or benzothiophenes,
- wherein Y is selected from 4- or 6-alkoxy, 4- or 6-alkyl or 4- or 6-halogen,
- wherein Z has the structure —(CH2)n—NR1R2,
- wherein R1 and R2 are selected from hydrogen and C1 to C10-alkyl, and
- wherein n is selected from 0, 1 and 2, and
- wherein Ar is selected from phenyl or substituted phenyl;
- and combinations thereof.
A method for activating Hedgehog signaling in hepatocytes comprising administration to an individual in need thereof an activator of the zinc finger protein GLI3 selected from the group consisting of:
- Sonic hedgehog (Shh), Indian hedgehog (Ihh), Desert hedgehog (Dhh), Smoothened agonist (SAG);
- compounds according to the following formula (1)
- wherein X is selected from thiophenes or benzothiophenes,
- wherein Y is selected from 4- or 6-alkoxy, 4- or 6-alkyl or 4- or 6-halogen,
- wherein Z has the structure —(CH2)n—NR1R2,
- wherein R1 and R2 are selected from hydrogen and C1 to C10-alkyl, and
- wherein n is selected from 0, 1 and 2, and
- wherein Ar is selected from phenyl or substituted phenyl;
- and combinations thereof.
Dependencies are inferred from the claim text.