Methods and compositions for the treatment of cancer
AssigneeUniversity of South Alabama
InventorsLalita Samant, Rajeev Samant, Shamik Das, Eddie Reed
Life of this patent
Estimating the term…
Abstract
Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for modulating the activity of the Hedgehog pathway.
Claims22
A method for treating or ameliorating a disorder in a subject with a reduced dosage of a therapeutic agent, said method comprising:
- reducing the level of a nucleic acid encoding GLI1 or the level of GLI1 protein in a cell of the subject, and
- administering an effective amount of the therapeutic agent to the subject, wherein the effective amount of the therapeutic agent is less than the effective amount of the therapeutic agent in the absence of the reduction of the level of a nucleic acid encoding GLI1 or the level of GLI1 protein in a cell of the subject.
A method for reducing the dosage of a therapeutic agent needed to treat a disorder in a subject comprising administering to the subject a nucleic acid comprising a sequence selected from SEQ ID NO.s:01-10, wherein the administration reduces the level of a nucleic acid encoding GLI1 or the level of GLI1 protein in a cell of the subject.
Dependencies are inferred from the claim text.