Compositions and methods for inhibiting hypdxia induced damage
AssigneesHealth Research, Inc., F. Hoffmann-La Roche AG
InventorsEugene Kandel, Evan Zynda, Brigitte Schott
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Abstract
Provided are compositions and methods for inhibiting hypoxia-induced damage. The compositions and methods involve the use of one or more agents that can inhibit one or any combination of the genes BCL2L14, BLOC1S2, C20RF42, CPT1A, FBP1, GCNT3, RHOB, SCIN, TACR1 and TNFAIP6. Polynucleotide and non-polynucleotide agents which can be used for inhibiting one or more of the genes are included. The method involves introducing one or more gene inhibiting agents to a cell, tissue, organ, or individual such that formation of hypoxia related damage is inhibited. Kits which contain the agents and printed information about using them for inhibiting hypoxia induced damage are also included.
Claims6
A method comprising delivering to an ex vivo organ in need of protection from hypoxia at least one agent that suppresses the expression and/or function of RHOB and also administering to the ex vivo organ an agent that suppresses the expression and/or function of TACR1.
Dependencies are inferred from the claim text.