Back to results
US 9,540,630 B2Granted
Optimization of alginate encapsulation of islets for transplantation
AssigneeBeta-O2 Technologies Ltd.
InventorsUriel Barkai, Avi Rotem, Dimitry Azarov, Tova Neufeld, Zohar Gendler
Life of this patent
Estimating the term…
Abstract
Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space (21) of a kidney (22) of a subject and is shaped to define a planar configuration. Other applications are also described.
Claims16
A method for controlling the blood glucose levels in a subject in need thereof, comprising:
- a. providing an implantable device having pancreatic islets containing insulin-producing cells in an amount sufficient to maintain blood glucose levels at a normal level in the subject, macroencapsulated in a three dimensional hydrogel, wherein the three dimensional hydrogel has a planar configuration and has a thickness from 300 microns to 500 microns wherein the amount sufficient to maintain blood glucose levels at a normal level in the subject is a density from 27,000 islets/cm3 to 43,750 islets/cm3;
- and
- b. implanting the implantable device in the subject,
- wherein following implantation, the implantable device maintains blood glucose levels at a normal level in the subject for at least 20 days.
1 more element
Dependencies are inferred from the claim text.