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US 9,540,628 B2Granted
Aminoacyl tRNA synthetases for modulating inflammation
AssigneeaTyr Pharma, Inc.
InventorsJeffry Dean Watkins, Alain Philippe Vasserot, Leslie Ann Greene, Ryan Andrew Adams, Kyle P. Chiang, Wei Zhang, Kristi Helen Piehl, Fei Hong, Alina He
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Abstract
Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Claims7
A composition comprising:
- a modified mRNA polynucleotide encoding a histidyl tRNA synthetase (HRS) polypeptide and a physiologically-acceptable carrier, where the HRS polypeptide is selected from (a) SEQ ID NO:28, (b) a fragment of SEQ ID NO:28 comprising at least 400 contiguous amino acids of SEQ ID NO:28, and (c) a variant which differs from SEQ ID NO:
- 28 by less than 10% of the residues of SEQ ID NO:
- 28, where the modified mRNA polynucleotide is operably linked to a heterologous translational regulatory element.
Dependencies are inferred from the claim text.