Regulator of complement activation and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsJohn D. Lambris, Christoph Schmidt, Daniel Ricklin
Life of this patent
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Abstract
A potent complement regulator is disclosed. The complement regulator comprises a complement regulatory region connected by a flexible linker to a multifunctional binding region that enables binding to C3b activation/inactivation products and/or oxidation end products, as well as to polyanionic surface markers on host cells. An embodiment of the invention utilizes factor H SCRs 1-4 as the complement regulatory region and factor H SCRs 19 and 20 as the multifunctional binding region, linked together by a poly-Gly linker at least 12 residues in length. Pharmaceutical compositions comprising the complement regulator and methods of using the complement regulator are also disclosed.
Claims19
A complement regulator comprising a complement regulating region that includes a plurality of complement control proteins (CCPs), linked by a flexible linker to a multifunctional binding region that enables binding of the complement regulator to (a) one or more C3b activation/inactivation products, (b) one or more oxidation end products and (c) one or more polyanionic surface markers on host cells, and wherein the flexible linker is of the same length and flexibility as a poly-Gly peptide at least 9, 10, 11 or 12 residues in length.
A polypeptide comprising, from N- to C-terminus, SCRs 1-4 of factor H, a poly-Gly linker at least 12 residues in length, and SCRs 19-20 of factor H.
Dependencies are inferred from the claim text.