Methods for programming differentiated cells into hematopoietic stem cells
AssigneeIcahn School of Medicine at Mount Sinai
InventorsIhor R. Lemischka, Kateri Moore, Carlos Filipe Pereira
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Abstract
The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription factors.
Claims22
A method for programming a differentiated cell into a hematopoietic stem cell, the method comprising introducing a combination of transcription factors in the differentiated cell, wherein the combination comprises GATA binding protein 2 (GATA2), growth factor independent 1B (GFI1B), and c-Fos.
Dependencies are inferred from the claim text.