Nitric oxide-releasing diazeniumdiolated polyvinylpyrrolidone-based polymers, and compositions, medical devices, and uses thereof
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsJoseph A. Hrabie, Larry K. Keefer
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Abstract
Disclosed is a nitric oxide-releasing polyvinylpyrrolidone-based polymer derived from N-vinylpyrrolidone monomer and at least one nitric oxide releasing N2O2− group, in which the N2O2− group is attached to a 2 pyrrolidinone group or a group derived therefrom in the N-vinylpyrrolidone monomer, and the polymer is optionally in combination with a substrate. The NO-releasing polymer can be part of a medical device or pharmaceutical composition and is useful for treating a biological disorder, such as healing a wound, restenosis, and/or promoting angiogenesis.
Claims20
A nitric oxide-releasing polyvinylpyrrolidone-based polymer comprising at least one monomer unit derived from N-vinylpyrrolidone and at least one monomer unit selected from the group consisting of formula (I) and formula (II)
- or a composite comprising the polymer in combination with a substrate, wherein R1 is —CH2CH2CR4R5C(O)OR6,
- R2, R3, R4, and R5 are the same or different and each is H or N2O2M,
- M is hydrogen ion or a pharmaceutically acceptable cation, and
- R6 is H, an unsubstituted or substituted C1-12 alkyl, an unsubstituted or substituted C2-8 alkenyl, an unsubstituted or substituted C3-C6 cycloalkyl, a substituted or unsubstituted aryl, or C1-12 trialkylsilyl, provided at least one of R2-5 is N2O2M in formula (I) and formula (II).
Dependencies are inferred from the claim text.