Polynucleotide encoding antibody to human IL-3 receptor alpha chain
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsTomonori Tawara, Shinichiro Takayanagi, Yoshimasa Inagaki
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Abstract
The present invention provides an antibody to human IL-3Rα chain, which does not inhibit IL-3 signaling and binds to B domain of the human IL-3Rα chain but does not bind to C domain of the human IL-3Rα chain; a composition for preventing or treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood of a subject, which comprises the antibody to human IL-3Rα as an active ingredient; and a method for treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood, which comprises administering, to a subject, a composition comprising the IL-3Rα antibody as an active ingredient.
Claims28
A polynucleotide encoding an antibody to a human IL-3Rα chain, wherein said antibody does not inhibit IL-3 signaling and binds to the B domain of the human IL-3Rα chain but does not bind to the C domain of the human IL-3Rα chain, and wherein said antibody binds to a region within positions 101-203 of SEQ ID NO:
- 2, but does not bind to any region within positions 204-308 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.