US 9,540,432 B2 · Anti-Aβ globulomer 7C6 antibodies

Abstract

Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies. The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.

Claims14

Dependent claims

An antibody selected from the group consisting of an isolated antibody, a monoclonal antibody and a recombinant antibody, wherein

(a) said antibody has a binding affinity to an Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to an Aβ(1-42) globulomer;
(b) the binding affinity of the antibody to the Aβ(20-42) globulomer is at least 10 times greater than the binding affinity of the antibody to the Aβ(1-42) globulomer;
(c) the antibody is humanized and binds to the same epitope as a monoclonal antibody 7C6 obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7240;
(d) the antibody comprises (i) a VH 7C6 CDR1 consisting of amino acid residues 31-35 of SEQ ID NO:
11, (ii) a VH 7C6 CDR2 consisting of amino acid residues 50-65 of SEQ ID NO:
11, (iii) a VH 7C6 CDR3 consisting of amino acid residues 98-107 of SEQ ID NO:11, (iv) a VL 7C6 CDR1 consisting of amino acid residues 24-39 of SEQ ID NO:
12, (v) a VL 7C6 CDR2 consisting of amino acid residues 55-61 of SEQ ID NO:
12, and (vi) a VL 7C6 CDR3 consisting of amino acid residues 94-102 of SEQ ID NO:12.

5 more elements

Dependencies are inferred from the claim text.

Anti-Aβ globulomer 7C6 antibodies

Life of this patent

Anti-Aβ globulomer 7C6 antibodies

Life of this patent

Abstract

Claims14