Extracellular matrix heparin-binding domains
AssigneeEcole Polytechnique Federale De Lausanne (Epfl)
InventorsJeffrey A. Hubbell, Mikael Martino, Laura De Laporte, Jeffrey J. Rice, Federico Tortelli
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Abstract
Heparin binding peptides derived from a Tenascin (TNC) III1-5 domain or a fibrinogen β15-66 domain have been found that bind certain cytokines with high affinity. Materials and methods for making compositions and devices using these peptides are disclosed.
Claims14
A biomaterial scaffold comprising a biomaterial matrix that comprises a synthetic polypeptide that comprises SEQ ID NO:8 or SEQ ID NO:9, with the biomaterial scaffold being pharmaceutically acceptable and free of fibrin.
A surface that is free of fibrin and free of fibrinogen comprising one or more immobilized moieties chosen from the group consisting of a synthetic peptide that comprises SEQ ID NO:8 or SEQ ID NO:9
- the surface being chosen from the group consisting of a stent, a vascular graft, a cell culture surface, a cell culture vessel, a cell carrier, and tissue culture plastic;
- said moieties being immobilized to the surface.
Dependencies are inferred from the claim text.