Peptide-based stat inhibitor
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsNadya I. Tarasova, Olga Timofeeva, Vadim Gaponenko, Christopher J. Michejda, Alan O. Perantoni, Sergey G. Tarasov
Life of this patent
Estimating the term…
Abstract
A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.
Claims14
An isolated peptide or peptidomimetic of 40 or fewer amino acids in length that binds to a STAT protein, wherein the peptide or peptidomimetic comprises at least one of:
- (a) the amino acid sequence of any of SEQ ID NOs:
- 32-34 or reverse thereof, wherein the amino acid sequence optionally is cyclized;
- (b) the amino acid sequence of Tyr Leu Xaa4 Gln Xaa3 Gln Xaa2 Leu Ala Xaa1 Gly Gln (SEQ ID NO:
- 66), wherein
- (i) Xaa1 is Asp or Glu,
- (ii) Xaa2 is Arg, His, or Lys,
- (iii) Xaa3 is norleucine (Nle) or Met, and
- (iv) Xaa4 is Val or Ala;
- or
- (c) the amino acid sequence of any of SEQ ID NOs:
- 11 or 38.
An isolated peptide or peptidomimetic of 40 or fewer amino acids in length that binds to a STAT protein, wherein the peptide or peptidomimetic comprises at least one of:
- (a) the amino acid sequence of any of SEQ ID NOs:
- 32-34 or retro-inverso version thereof;
- (b) the amino acid sequence of Tyr Leu Xaa4 Gln Xaa3 Gln Xaa2 Leu Ala Xaa1 Gly Gln (SEQ ID NO:
- 66) or inverse thereof, wherein
- (iii) Xaa1 is Asp or Glu,
- (iv) Xaa2 is Arg, His, or Lys,
- (iii) Xaa3 is norleucine (Nle) or Met, and
- (iv) Xaa4 is Val or Ala;
- or
- (c) the amino acid sequence of SEQ ID NO:
- 11 or retro-inverso version thereof.
Dependencies are inferred from the claim text.