US 9,540,418 B2 · Polypeptide specifically binding to rare earth nanoparticles and use thereof

Abstract

The present invention provides a polypeptide able to specifically bind to rare-earth nanoparticles and the use thereof. The polypeptide comprises an amino acid sequence shown by SEQ ID NO: 1 or analogs thereof. The present invention further provides a method for screening a polypeptide having the capacity of specifically binding to rare-earth nanoparticles. The present invention further provides a method for regulating and controlling the in vivo and in vitro autophagy and toxicity of the rare-earth upconversionnanophosphor material, comprising mixing and incubating the polypeptide specifically binding to rare-earth nanoparticles with rare-earth upconversion nanophosphor material, such that the polypeptide specifically binds to the nanophosphor material, wherein the rare-earth upconversion nanophosphor material comprises the rare earth, and the polypeptide specifically binding to rare-earth nanoparticles comprises the amino acid sequence shown by CTARSPWIC (RE-0, SEQ ID NO: 1) or analogs thereof.

Claims23

Dependent claims

A polypeptide specifically binding to a rare-earth nanoparticle, wherein the polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:

2, SEQ ID NO:
3, SEQ ID NO:
4, SEQ ID NO:
5, SEQ ID NO:
7, SEQ ID NO:
9, SEQ ID NO:
10, SEQ ID NO:
11, SEQ ID NO:
12, SEQ ID NO:
13, SEQ ID NO:
14, SEQ ID NO:
15, SEQ ID NO:
17, SEQ ID NO:
19, SEQ ID NO:
21, SEQ ID NO:
23, SEQ ID NO:
25, SEQ ID NO:
27, SEQ ID NO:
29, and SEQ ID NO:
31.

17 more elements

Dependencies are inferred from the claim text.

Polypeptide specifically binding to rare earth nanoparticles and use thereof

Life of this patent

Polypeptide specifically binding to rare earth nanoparticles and use thereof

Life of this patent

Abstract

Claims23