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US 9,540,406 B2Granted
Process for fosaprepitant
AssigneeHetero Research Foundation
InventorsBandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Dasari Muralidhara Reddy, Thungathurthy Srinivasa Rao, Bandi Vamsi Krishna
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Abstract
The present invention provides a novel process for reducing palladium content in fosaprepitant dimeglumine.
Claims14
A process for reducing palladium content in fosaprepitant dimeglumine, which comprises:
- a. providing a solution of fosaprepitant dimeglumine in a solvent;
- b. adding a metal scavenger to the solution obtained in step (a);
- c. maintaining the reaction mass obtained in step (b) at room temperature;
- d. adding a solvent to the reaction mass;
- e. isolating the wet solid;
- f. slurring the wet solid obtained in step (e) with an ester solvent;
- and
- g. isolating fosaprepitant dimeglumine having single digit ppm of residual palladium;
- wherein the metal scavenger is
6 more elements
A process for reducing palladium content in fosaprepitant dimeglumine, which comprises:
- a. providing a solution of dibenzyl fosaprepitant in a solvent;
- b. subjecting the solution to hydrogenation in the presence of palladium carbon and N-methyl-D-glucamine;
- c. adding a metal scavenger to the reaction mass obtained in step (b);
- d. maintaining the reaction mass at room temperature;
- e. removing the solvent from the reaction mass to obtain a residual solid;
- f. adding nitrile solvent to the residual solid obtained in step (e);
- and
- g. isolating fosaprepitant dimeglumine having single digit ppm of residual palladium, wherein the metal scavenger is
5 more elements
Dependencies are inferred from the claim text.