Back to results
US 9,540,393 B2Granted
Inhibitors of human immunodeficiency virus replication
AssigneeViiV HEALTHCARE UK (NO.5) LIMITED
InventorsB. Narasimhulu Naidu, Manoj Patel, Stanley D'Andrea, Zhizhen Barbara Zheng
Life of this patent
Estimating the term…
Abstract
The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
Claims15
A compound of Formula I
- where:
- R1 is hydrogen or alkyl;
- R2 is hydrogen or alkyl;
- R3 is hydrogen, alkyl or halo;
- X1 is —CONH—, —CONHCH2CO—, —CONHCH2C(OH)H—, or —NH—;
- X2 is absent or benzyl wherein the benzyl can be substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, alkoxy, and haloalkoxy;
- X3 is O or absent when X2 is absent;
- X4 is alkylene or alkenylene;
- X5 is O or absent;
- and
- X6 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 halo or alkyl substituents;
- or X6 is phenyl or oxazinyl and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, alkoxy, and haloalkoxy;
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.