US 9,540,388 B2 · P2X7 modulators

Abstract

The present invention is directed to a compound of Formula (I): wherein: The present invention is directed to a compound of Formula (I): wherein: •n is an integer from 0-1; •X is CH2 when n is 0, or X is CH2 or oxygen when n is 1; •R1 is phenyl or pyridinyl, wherein the phenyl or pyridinyl is optionally substituted with from 1 to 4 substituents independently selected from halogen and alkyl; and •R2 is S phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl, wherein the phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl is optionally substituted with from 1 to 2 substituents independently selected from the group consisting of halogen, alkyl, hydroxy and alkoxy. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). The compounds of formula (I) are useful as P2X7 modulators.

Claims35

Dependent claims

A compound of formula I

or an enantiomer or diastereomer thereof;
or a pharmaceutically acceptable salt thereof;
wherein:
n is an integer from 0-1;
X is CH2 when n is 0, or X is CH2 or oxygen when n is 1;
R1 is phenyl or pyridinyl, wherein the phenyl or pyridinyl is optionally substituted with from 1 to 4 substituents independently selected from halogen and alkyl;
and
R2 is phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl, wherein the phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl is optionally substituted with from 1 to 2 substituents independently selected from the group consisting of halogen, alkyl, hydroxy and alkoxy.

5 more elements

A compound selected from the group consisting of:

11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyrimidin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyrimidin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyrimidin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(1,3-thiazol-4-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(1,3-thiazol-4-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(1,3-thiazol-4-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoropyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoropyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoropyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-3-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-3-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-3-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoropyrimidin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoropyrimidin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoropyrimidin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-[(2,4-Dichlorophenyl)carbonyl]-3-(5-fluoropyrimidin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-[(2,4-Dichlorophenyl)carbonyl]-3-(5-fluoropyrimidin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-[(2,4-Dichlorophenyl)carbonyl]-3-(5-fluoropyrimidin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(6-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(6-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(6-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-methoxypyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-methoxypyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-methoxypyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
3-(5-Chloropyridin-2-yl)-11-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-3-(5-Chloropyridin-2-yl)-11-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-3-(5-Chloropyridin-2-yl)-11-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[3-Chloro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-3-thiophen-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[3-Chloro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-3-thiophen-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[3-Chloro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-3-thiophen-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
11-{[3-Chloro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-3-(5-methylthiophen-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,10R)-11-{[3-Chloro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-3-(5-methylthiophen-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[3-Chloro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-3-(5-methylthiophen-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-fluorophenyl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyrazin-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-4-fluoro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Methyl-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoropyridin-2-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyrimidin-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-[(2,3-Dichloro-4-fluorophenyl)carbonyl]-3-pyrazin-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-3-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(1,3-thiazol-4-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoropyrimidin-2-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(3-methyl-1H-pyrazol-5-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-4-fluoro-3-(trifluoromethyl)phenyl]carbonyl}-3-(1,3-thiazol-4-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Methyl-3-(trifluoromethyl)phenyl]carbonyl}-3-(1,3-thiazol-4-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-[(2,4-Dichloro-3-fluorophenyl)carbonyl]-3-(1,3-thiazol-4-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-3-(5-Chlorothiophen-2-yl)-10-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(2-methyl-1,3-thiazol-4-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(1,3-thiazol-5-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-thiophen-3-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-methyl-1,3-thiazol-5-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-3-(5-Chlorothiophen-2-yl)-10-{[3-chloro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-thiophen-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(6S,9R)-10-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(1H-pyrrol-2-yl)-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine;
(2-chloro-4-fluoro-3-(trifluoromethyl)phenyl)(3-(pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)(3-(pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(3-chloro-2-(trifluoromethyl)pyridin-4-yl)(3-(pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
((2-methyl-3-(trifluoromethyl)phenyl)(3-(pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(3-methyl-2-(trifluoromethyl)pyridin-4-yl)(3-(pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)(3-(pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2,4-dichloro-3-fluorophenyl)(3-(pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)(3-(pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(3-fluoropyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(3,5-difluoropyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
((2-chloro-3-(trifluoromethyl)phenyl)(3-(5-fluoro-6-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(5-fluoro-4-methoxypyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(4-(trifluoromethoxy)pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(4-(difluoromethoxy)pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(4-hydroxypyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(4-ethoxypyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(4-isopropoxypyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(5-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(4-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(4-(trifluoromethyl)pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(5-fluoro-4-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)(3-(5-fluoro-4-(trifluoromethyl)pyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyrazin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(pyrazin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-methyl-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyrazin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyrazin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(pyrazin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(pyrazin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(pyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-methyl-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(pyrazin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(pyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(5-fluoropyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(5-fluoropyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(5-fluoropyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(5-fluoropyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(5-fluoropyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(5-fluoropyrimidin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(5-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(5-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(5-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(5-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(5-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(5-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-(trifluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(4-(trifluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-methyl-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-(trifluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-(trifluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(4-(trifluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(4-(trifluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-methyl-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(5-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(5-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(5-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(5-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(5-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(5-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,1 OS)-3-(1H-pyrazol-3-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-chloro-3-(trifluoromethyl)phenyl)methanone;
((6R,1 OS)-3-(1H-pyrazol-3-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2,3-dichloro-4-fluorophenyl)methanone;
((6R,1 OS)-3-(1H-pyrazol-3-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
((6R,1 OS)-3-(1H-pyrazol-3-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-fluoro-3-(trifluoromethyl)phenyl)methanone;
((6R,1 OS)-3-(1H-pyrazol-3-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)methanone;
((6R,10S)-3-(1H-pyrazol-3-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2,3-dichlorophenyl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-fluorophenyl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(4-fluorophenyl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(4-fluorophenyl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-fluorophenyl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(4-fluorophenyl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(4-fluorophenyl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(3-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(3-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(3-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(3-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(3-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(3-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-(difluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(4-(difluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(4-(difluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
((6R,10S)-3-(4-(difluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-fluoro-3-(trifluoromethyl)phenyl)methanone;
((6R,10S)-3-(4-(difluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(4-(difluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(5-fluoro-6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(5-fluoro-6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(5-fluoro-6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(5-fluoro-6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(4-(difluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(5-fluoro-6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-(trifluoromethyl)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(4-(trifluoromethyl)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-methyl-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-(trifluoromethyl)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(4-(trifluoromethyl)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(4-(trifluoromethyl)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(4-(trifluoromethyl)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-methyl-3-(trifluoromethyl)phenyl)((6R,10S)-3-(6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(6-methylpyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(3-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(3-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
((6R,10S)-3-(3-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)(2-methyl-3-(trifluoromethyl)phenyl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(3-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(3-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(3-fluoropyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(thiazol-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(thiazol-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-methyl-3-(trifluoromethyl)phenyl)((6R,10S)-3-(thiazol-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(thiazol-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(thiazol-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(thiazol-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-chloro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(thiazol-4-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(thiazol-4-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-methyl-3-(trifluoromethyl)phenyl)((6R,10S)-3-(thiazol-4-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2-fluoro-3-(trifluoromethyl)phenyl)((6R,10S)-3-(thiazol-4-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)((6R,10S)-3-(thiazol-4-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(2,3-dichlorophenyl)((6R,10S)-3-(thiazol-4-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoro-6-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(4-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridazin-3-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-[4-(trifluoromethyl)pyridin-2-yl]-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyrimidin-4-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[3-Chloro-2-(trifluoromethyl)pyridin-4-yl]carbonyl}-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
6R,10S)-11-{[2-Chloro-4-fluoro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-{[2-Methyl-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
(6R,10S)-11-[(2,4-Dichloro-3-fluorophenyl)carbonyl]-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine;
and
(6R,10S)-11-[(2,3-Dichloro-4-fluorophenyl)carbonyl]-3-pyridin-2-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine.

201 more elements

Dependencies are inferred from the claim text.

P2X7 modulators

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P2X7 modulators

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Abstract

Claims35