Anti-angiogenesis compound, intermediate and use thereof
AssigneeGuangzhou Kangrui Biological Pharmaceutical Technology Co., Ltd.
InventorsRui Hou, Gen Li
Life of this patent
Estimating the term…
Abstract
Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.
Claims12
A compound as represented by formula I or a pharmaceutically acceptable salt thereof,
- wherein, R1 is selected from H, amino, hydroxy or sulfydryl, R2 is selected from H, amino, hydroxy, sulfydryl or —(CH2)nNHR8, wherein n=1-5, R8 is H or C1-3 alkyl;
- R3 is selected from H or C1-6 alkyl;
- R4, R5 and R6 are each independently selected from H, halogen, C1-6 alkyl or halogen substituted alkyl;
- and R7 is selected from H, C1-6 alkyl or halogen;
- or, R2 and R3 together with the carbon atom connecting them form substituted or unsubstituted 5- or 6-membered ring having 1 to 2 heteroatoms, wherein the heteroatoms are N, O or S, and the substituent is C1-6 alkyl.
An intermediate compound as represented by formula II:
- wherein R4, R5 and R6 are each independently selected from H, halogen, C1-6 alkyl or halogen substituted alkyl, R7 is selected from H, C1-6 alkyl or halogen.
Dependencies are inferred from the claim text.