Substituted spirocycles
AssigneeBoehringer Ingelheim International GmbH
InventorsViktor Vintonyak, Matthias Grauert, Marc Grundl, Alexander Pautsch
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Abstract
This invention relates to a compound of formula I wherein A and Cy have one of the meanings as indicated in the specification and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
Claims30
A compound of formula I or a pharmaceutically acceptable salt thereof,
- wherein
- Cy is
- A is
- wherein
- W is selected from the group consisting of CH and N;
- X is selected from the group consisting of CH and N;
- Y is selected from the group consisting of CH and N;
- with the proviso that a maximum of one of W, X and Y can be N;
- D-E is selected from the group consisting of N(R2)—C(O), CH2CH2, C(O)—O and CH2—O;
- R2 is selected from the group consisting of H and C1-3-alkyl;
- R1 is selected from the group consisting of H, C1-3-alkyl, CH3OCH2CH2—, oxetanyl, tetrahydrofuranyl, 4-tetrahydropyranyl and 3-tetrahydropyranyl;
- i is 1, 2 or 3;
- j is 1, 2 or 3;
- with the proviso that the sum of i+j is 2, 3 or 4.
A compound of formula I, selected from the group consisting of examples 1, 5, 8, 10, 12, 13, 14, 19, 22, 23, 24, 25 and 27 (shown below):
Dependencies are inferred from the claim text.