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US 9,540,369 B2Granted
Use of kinase inhibitors to increase the susceptibility of gram positive bacteria to beta lactam antibiotics
AssigneeWisconsin Alumni Research Foundation
InventorsRobert Todd Striker, John-Demian Sauer, Nathan Wlodarchak
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Abstract
Methods of using certain kinase inhibitors for treating Gram positive bacterial infections are disclosed. When co-administered with a β-lactam antibiotic, the disclosed compounds increase the susceptibility of infectious Gram positive bacteria to the β-lactam antibiotic. The disclosed kinase inhibitors have either of the general formulas: or the specific formula:
Claims9
A method of treating a Gram positive bacterial infection in a subject in need thereof, comprising administering to said subject an effective amount of a compound having the chemical structure:
- wherein one of R1 and R2 is H;
- wherein the other of R1 and R2 is —OX, wherein X is selected from the group consisting of
- wherein R3 is selected from the group consisting of —CH2CH3,
- and wherein R4 is selected from the group consisting of
- or a pharmaceutically acceptable salt.
2 more elements
Dependencies are inferred from the claim text.