Compounds for bone growth

A compound according to Formula I:

• or a salt or hydrate thereof;
• wherein
• W is CR3a;
• X is selected from CR3b and N, wherein N is optionally oxidized to the corresponding N-oxide;
• Y is selected from CR3c and N, wherein N is optionally oxidized to the corresponding N-oxide;
• Z is CR3d;
• RN is selected from the group consisting of
• and wherein any N in RN is optionally oxidized to the corresponding N-oxide;
• each R1a, R1b, and R1c is independently selected from H, methyl, and ethyl, wherein the total number of carbon atoms in the group —C(R1a)2—[C(R1b)2]q—[C(R1c)2]t— does not exceed six;
• each R3a, R3b, and R3c is independently selected from the group consisting of H, halogen, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 haloalkoxy, aryloxy, C1-6 alkyl-OH, —OR4, —C0-6 alkyl-NR4R5, —SR4, —C(O)R4, —C0-6 alkyl-C(O)OR4, —C(O)NR4R5, —N(R4)C(O)R5, —N(R4)C(O)OR5, —N(R4)C(O)NR4R5, —OP(O)(OR4)2, —S(O)2OR4, —S(O)2NR4R5, —CN, cycloalkyl, heterocycloalkyl, aryl and heteroaryl;
• each R2 and R3d is independently selected from the group consisting of halogen, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 haloalkoxy, aryloxy,C1-6 alkyl-OH, —OR4, —C0-6 alkyl-NR4R5, —SR4, —C(O)R4, —C0-6 alkyl-C(O)OR4, —C(O)NR4R5, —N(R4)C(O)R5, —N(R4)C(O)OR5, —N(R4)C(O)NR4R5, —OP(O)(OR4)2, —S(O)2OR4, —S(O)2NR4R5, —CN, cycloalkyl, heterocycloalkyl, aryl and heteroaryl;
• each of R4 and R5 is independently selected from the group consisting of H, C1-6 alkyl, and C1-6 alkyl-OH;
• the subscript q is an integer from 0 to 4;
• and
• the subscript t is an integer from 0 to 4;
• provided that no more than one of X and Y is N or the corresponding N-oxide.