Prolyl hydroxylase inhibitors
AssigneeAerpio Therapeutics Inc.
InventorsJoseph H. Gardner, Robert Shalwitz
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Abstract
Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1α), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.
Claims12
A compound of the formula:
- wherein Z has the formula:
- each R is independently a halogen;
- n is an integer from 1 to 5;
- and
- R4 is alkyl;
- or
- a pharmaceutically-acceptable salt thereof.
A method for treating an infection, the method comprising administering to a subject in need thereof a therapeutically-effective amount of a compound having the formula:
- wherein Z has the formula:
- each R is independently a halogen;
- n is an integer from 1 to 5;
- and
- R4 is alkyl;
- or
- a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.