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US 9,540,318 B2Granted
Sulfonamide compounds and their use in the modulation retinoid-related orphan receptor
AssigneeGlaxo Group Limited
InventorsVéronique Birault, Amanda Jennifer Campbell, Stephen Harrison, Joelle Le
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Abstract
The present invention is directed to novel retinoid-related orphan receptor gamma (RORγ) modulators, processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by RORγ.
Claims15
A compound of formula (I), or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is CH3 or halo;
- R2,R3 and R4 are H;
- R5 is CH3 or halo;
- R6 is selected from the group consisting of C3-5alkyl and —CH2—C3-4 cycloalkyl;
- R7 is selected front the group consisting of
- R8 is selected from the group consisting of C1-3alkyl, C1-3alkoxy, CH2CN, CH2OH, OH, CN and halo;
- R9 is the group —(CHR10)s—(X)t—(CHR10)u—R11;
- each R10 is independently selected from the group consisting of H, OH or CH2OH;
- R11 is selected from the group consisting of
- optionally substituted with one or two substituents selected from halo, NH2 or CH3;
- X is CH2, NH, O;
- r is 0, 1 or 2;
- s is 0, 1 or 2;
- t is 0 or 1;
- u is 0, 1 or 2;
- with the proviso that no more than two R10 groups represent OH or CH2OH.
14 more elements
Dependencies are inferred from the claim text.