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US 9,540,307 B2Granted
Statins of omega-3 polyunsaturated acids for treating hypercholesterolemia
AssigneeJiva Pharma, Inc.
InventorOm P Goel
Life of this patent
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Abstract
The present invention relates to novel statin derivatives of omega-3 fatty acids, and their use in treating hypercholesterolemia, obesity, hypertriglyceridemia, cardiovascular diseases, and metabolic diseases, and Alzheimer's disease.
Claims7
A compound of Formula (I) or Formula (II) having the formula:
- wherein:
- R is joined from the aldehyde group formed by the partial reduction of the carboxylic acid of:
- cis,cis,cis-7,10,13-hexadecatrienoic acid (HTA) of the following structure:
- cis,cis,cis-9,12,15-octadecatrienoic acid (ALA) of the following structure:
- cis,cis,cis,cis-6,9,12,15-octadecatetraenoic acid (SDA) of the following structure:
- cis,cis,cis-11,14,17-eicosatrienoic acid (ETE) of the following structure:
- cis,cis,cis,cis-8,11,14,17-eicosatetraenoic acid (ETA), of the following structure:
- cis,cis,cis,cis-5,8,11,4,17-eicosapentanenoic acid (EPA) of the following structure:
- cis,cis,cis,cis,cis-6,9,12,15,18-heneicosapentaenoic acid (HPA) of the following structure:
- cis,cis,cis,cis,cis-7,10,13,16,19-docosapentaenoic acid (DPA) of the following structure:
- cis,cis,cis,cis,cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) of the following structure:
- cis,cis,cis,cis-9,12,15,18,21-tetracosapentaeonic acid (TPA) of the following structure:
- or
- cis,cis,cis,cis,cis,cis-6,9,12,15,18,21-tetracosahexaeonic acid (THA) of the following structure:
- or
- the pharmaceutically-acceptable salts of Formula (II).
13 more elements
Dependencies are inferred from the claim text.