MTOR-independent activator of TFEB for autophagy enhancement and uses thereof
AssigneeHong Kong Baptist University
InventorsMin Li, Juxian Song, Chuanbin Yang, Yu Zeng, Sandeep Malampati, Hongjie Zhang
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Abstract
The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed.
Claims10
A method for enhancing autophagy in cells comprising providing a mono-carbonyl analog of curcumin having a formula of
A method of treating neurodegenerative diseases comprising administering a composition comprising a mono-carbonyl analog of curcumin having a formula of
A method of enhancing lysosome biogenesis in cells comprising providing the mono-carbonyl analog of
A method of promoting the degradation of Tau aggregates in cells of a subject in need thereof comprising administering a composition comprising a mono-carbonyl analog of curcumin having a formula of C1:
- 1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one.
Dependencies are inferred from the claim text.