US 9,540,154 B2Granted

Closure for a container and method for carrying out a freeze-drying process

AssigneeDatwyler Pharma Packaging International NV

InventorsRonny Prosper Elisabeth Vrijens, Reinhard Louis Jozef Waeben

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Abstract

A closure (1) for a container (9), or for an ampoule (9), in which a medicament is accommodated, having a closure cap (2) and a closure stopper (5) accommodated in the closure (2). Detent moldings (6) are formed on the closure cap (2) for latchingly holding the closure (1) on the ampoule (9), and a sliding part (3) is provided which is movable relative to the closure cap (2) in order to displace the closure stopper (5) into the closed position. In order to advantageously provide, with respect to carrying out a freeze-drying process, a closure for a container, or for an ampoule, in which a medicament is accommodated, the closure stopper (5) is displaceable relative to the cap (2) by means of the sliding part (3) in order to move the closure stopper into the closed position. There is also a method for carrying out a freeze-drying process for a medium, or for a medicament, which is accommodated in a container, or in an ampoule (9).

Claims25

Dependent claims

A closure (1) for an ampoule (9), in which a medicament is accommodated, comprising

a closure cap (2) and a closure stopper (5) accommodated in the closure (2), detent moldings (6) being formed on the closure cap (2) for latchingly holding the closure (1) on the ampoule (9), and a sliding part (3) being provided which is movable relative to the closure cap (2) in order to displace the Closure stopper (5) into a closed position,
wherein the closure stopper (5) is displaceable relative to the closure cap (2) by means of the sliding part (3) in order to move the closure stopper into the closed position;
wherein the closure stopper has a flange (11), as well as an insertion portion which extends downwardly from the flange;
wherein the sliding part acts on the flange (11) by means of a pushing projection (10);
wherein the pushing projection (10) is formed on the sliding part, and
wherein the flange (11) rests in the closed position on an end face of a bead (7) of the ampoule (9);
and
wherein the stopper and the sliding part are separate elements;
wherein in the closed position, the sliding part is moved downwardly relative to the closure cap;
wherein the sliding part acts on an upper surface of the flange of the stopper;
and
wherein the stopper is moveable from an open position with the flange being distant to the bead into the closed position with the flange in sealing contact with the bead;
wherein the stopper (5) does completely seal an inner side of the ampoule in its sealing position;
wherein the sliding part is not turnable relative to the closure cap;
wherein the sliding part in the closed position is latched against the cap (2);
wherein the wall of the closure cap (2) has openings for allowing vapor/gas to escape from the ampoule in order
to perform a freeze-drying procedure and/or to have means to check by eye whether the stopper is within the cap or not.

14 more elements

A method for carrying out a freeze-drying process for a medium, or for a medicament, accommodated in an ampoule (9), comprising

closing the ampoule (9) by means of a closure stopper (5) which seals in a region of an ampoule opening, with the flange in sealing contact with a bead (7), in addition the closure stopper (5) being initially held in a closure cap (2), mounted on the ampoule (9) before starting a drying, in a position at a distance from the region, and being moved into a sealing position after the drying is completed,
wherein after the drying is completed, the closure stopper (5) is moved into a closed position by action of a sliding part (3), with the closure cap (2) stationary relative to the ampoule, that is displaceably guided on the closure cap (2);
wherein the closure stopper has a flange (11), and an insertion portion which extends downwardly from the flange;
wherein the sliding part acts on the flange (11) by means of a pushing projection (10);
wherein the pushing projection (10) is formed on the sliding part, and
wherein the flange (11) rests in the closed position on an end face of the bead (7) of the ampoule (9);
and
wherein the stopper and the sliding part are separate elements;
wherein in the closed position, the sliding part is moved downwardly relative to the closure cap;
wherein the sliding part acts on an Upper surface of the flange of the stopper;
and
wherein the stopper is moveable from an open position with the flange being distant to the bead into the closed position with the flange in sealing contact with the bead;
and
wherein the stopper (5) does completely seal an inner side of the ampoule in its sealing position;
wherein the sliding part is not turnable relative to the closure cap;
wherein the sliding part in the closed position is latched against the closure cap (2);
wherein the wall of the closure cap (2) has openings for allowing vapor/gas to escape from the ampoule in order
to perform the freeze-drying process and/or to have means to check by eye whether the stopper is within the cap or not.

15 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/697,094Filed 6 May 2011
Priority: DE 10 2010 016 86610 May 2010
Published: US 2013/0055681 A17 Mar 2013
Granted: 10 Jan 2017
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

B65D 51/241
Combined or co-operating with auxiliary devices for non-closing purposes: provided with freeze-drying means
A61J 1/1406
Details; Accessories therefor: septums, pierceable membranes
A61J 1/1475
Details; Accessories therefor: inlet or outlet ports
B65D 47/247
The valve being opened or closed by actuating a stopper-type element: moving linearly, i.e. without rotational motion