Long-acting limus formulation on balloon catheters
AssigneeInnoRa GmbH
InventorDaniel Peters
Life of this patent
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Abstract
The invention relates to balloon catheters having a polymer-free coating on the balloon surface, said coating comprising at least one limus substance in crystalline form, and to methods for the polymer-free coating of balloon surfaces, in particular balloon catheters, with crystalline limus substances.
Claims18
An angioplasty balloon catheter with a polymer-free coating on a balloon surface, comprising at least one limus substance in an un-encapsulated crystalline form, wherein the un-encapsulated crystalline limus substance was applied directly from a solvent mixture of at least one polar organic solvent and at least one apolar organic solvent.
An angioplasty balloon catheter having a polymer-free coating on a balloon surface, comprising at least one limus substance in an un-encapsulated crystalline form, wherein the un-encapsulated crystalline limus substance was applied as a suspension from a solvent mixture of at least one polar organic solvent and at least one apolar organic solvent.
A method for polymer-free coating of balloon surfaces of angioplasty balloon catheters having crystalline limus substances, comprising the following steps:
- a) dissolving at least one limus substance in a polar organic solvent to form a solution,
- b) mixing the solution from a) with an apolar organic solvent so that either a supersaturated solution is formed or a true solution is maintained,
- then either
- c) applying the supersaturated solution or the true solution to the balloon surface and crystallization
- or
- d) in the case of a supersaturated solution, dissolving the crystals of the at least one limus substance to yield a suspension that contains crystals and
- either
- d1) applying the suspension to the balloon surface and performing additional crystallization and/or drying there
- or
- d2) isolating the crystals of the at least one limus substance from the suspension with optional drying and re-suspension of the crystals in a suitable liquid and applying the re-suspension to the balloon surface and performing additional crystallization and/or drying.
Dependencies are inferred from the claim text.