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US 9,539,362 B2Granted
Method for forming inorganic coatings
AssigneeTrustees of Tufts College
InventorsDavid L. Kaplan, Chunmei Li
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Abstract
The present invention is directed to a method for forming an inorganic coating on a protein template. The method comprises contacting the template with an anionic polymer interface followed by an inorganic material for a sufficient period of time to allow mineralization of the inorganic material thus forming an inorganic coating on the template. Preferably, the coating is aligned.
Claims14
A matrix comprising
- an aligned inorganic coating on a protein template comprising silk fibroin,
- wherein the protein template further comprises an anionic polymer,
- wherein the anionic polymer interacts with the protein template so that a surface is established that promotes nucleation and growth of inorganic crystals,
- wherein the anionic polymer comprises poly-L-aspartic acid and the aligned inorganic layer comprises hydroxyapatite, and
- wherein the weight ratio of the poly-L-aspartic acid to the silk fibroin is between 200 mg/g and 1 g/g, inclusive.
2 more elements
A silk fibroin template comprising
- an aligned inorganic coating, and
- at least one therapeutic or biologically active agent,
- wherein the silk fibroin template comprises an anionic polymer,
- wherein the anionic polymer interacts with the silk fibroin template and promotes more regular nucleation and growth of inorganic crystals,
- wherein the anionic polymer comprises poly-L-aspartic acid and the aligned inorganic layer comprises hydroxyapatite, and
- wherein the weight ratio of the poly-L-aspartic acid to the silk fibroin is between 200 mg/g and 1 g/g, inclusive.
3 more elements
Dependencies are inferred from the claim text.