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US 9,539,350 B2Granted
Formulation, apparatus and method for stabilizing radiopharmaceuticals
AssigneeSiemens Medical Solutions USA, Inc.
InventorsHartmuth C. Kolb, Joseph C. Walsh, Vani P. Mocharla, Fanrong Mu, Umesh Gangadharmath
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Abstract
A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
Claims13
An apparatus for stabilizing a radiopharmaceutical, the apparatus comprising:
- a container having:
- a formulation comprising:
- a F18 labelled radiopharmaceutical, or a pharmaceutically acceptable salt of a F-18 labelled radiopharmaceutical thereof;
- a gas comprising oxygen, wherein the oxygen is present in the gas in
- an amount of at least about 10 vol. % by total volume of gas, and where the gas is disposed in a headspace of a vial containing the F-18 labelled radiopharmaceutical or the pharmaceutically acceptable salt of the F-18 labelled radiopharmaceutical;
- an alcohol;
- a stabilizer, wherein the stabilizer is maleic acid.
4 more elements
Dependencies are inferred from the claim text.