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US 9,539,349 B2Granted
Formulation, apparatus and method for stabilizing radiopharmaceuticals
AssigneeSiemens Medical Solutions USA, Inc.
InventorsHartmuth C. Kolb, Joseph C. Walsh, Vani P. Mocharla, Fanrong Mu, Umesh Gangadharmath
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Abstract
A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
Claims2
A method of making a formulation for stabilizing a radiopharmaceutical, the method comprising:
- providing a F18 labelled radiopharmaceutical, or a pharmaceutically acceptable salt of a F-18 labelled radiopharmaceutical thereof in a vial;
- providing an aqueous solution of an alcohol and an inorganic salt in the vial;
- providing a gas comprising oxygen in the vial;
- wherein the oxygen is present in the gas in an amount of at least about 10 vol. % by total volume of gas;
- providing an excipient in the vial, wherein the excipient is maleic acid.
2 more elements
Dependencies are inferred from the claim text.