Affinity peptide-modified particles and targeted drug delivery methods
AssigneeThe Children's Hospital of Philadelphia
InventorsRobert J. Levy, Michael Chorny
Life of this patent
Estimating the term…
Abstract
A therapeutic particle comprises a particle comprising one or more therapeutic agents and one or more fibrin-avid peptide variants attached to the surface of the particle. A method for magnetically targeting a therapeutic agent toward a device in a subject, such as a temporarily introduced magnetizable catheter or an implanted stent, comprises administering the therapeutic particles to the subject and generating a magnetic field, which targets the magnetic particles toward the device. The affinity peptide-modified therapeutic particles may comprise an effective amount of an anti-proliferative agent, such as paclitaxel, to inhibit or prevent in-stent restenosis.
Claims33
A therapeutic particle comprising:
- a particle comprising one or more therapeutic agents, wherein one or more fibrin-avid peptide variants are attached to the surface of the particle, and wherein the one or more fibrin-avid peptide variants have the amino acid sequence selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9.
Dependencies are inferred from the claim text.