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US 9,539,335 B2Granted
Diclofenac topical formulation
AssigneeHZNP Limited
InventorsEd Kisak, Jagat Singh
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Abstract
The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical treatment of pain, such as in osteoarthritis.
Claims19
A process for making a topical formulation, comprising:
- adding hydroxypropyl cellulose to a mixture of dimethylsulfoxide, water, diclofenac sodium, propylene glycol, and ethanol, wherein the topical formulation consists of:
- diclofenac sodium present at 2% w/w;
- DMSO present at about 40 to about 50% w/w;
- ethanol present at 23-29 w/w %;
- propylene glycol present at 10-12% w/w;
- hydroxypropyl cellulose;
- and
- water to make 100% w/w;
- wherein the formulation has a viscosity of 500-5000 centipoise.
6 more elements
Dependencies are inferred from the claim text.