Plasticizers for coating compositions
AssigneeAbbott Cardiovascular Systems Inc.
InventorsStephen Dirk Pacetti, Yiwen Tang, Syed Faiyaz Ahmed Hossainy
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Abstract
A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Claims21
A polymeric coating for an implantable device, the coating comprising a biocompatible polymer and a biocompatible plasticizer, the plasticizer being in the range between 0.1% and 40% by weight of the coating;
- wherein the plasticizer is a linear oligomer of a monomer selected from the group consisting of glycolic acid, L-lactic acid, D-lactic acid, D, L-lactic acid, 3-hydroxypropanoic acid, 3-hydroxybutyric acid, 4-hydroxybutyric acid, 3-hydroxyvalerate, 4-hydroxyvalerate, 5-hydroxyvalerate, 3-hydroxyhexanoate, 4-hydroxyhexanoate, 5-hydroxyhexanoate, ε-caprolactone, 6-hydroxycaproic acid, γ-butyrolactone, β-butyrolactone and combinations thereof;
- and
- wherein the linear oligomer is a dimer, a trimer, a tetramer, or a combination thereof.
Dependencies are inferred from the claim text.