HMGB1-derived peptides enhance immune response to antigens
AssigneeThe Regents of the University of California
InventorsDavorka Messmer, Rebecca Saenz
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Abstract
The invention provides an immtmostimulatory peptide containing the amino acid sequence SAFFLFCSE and uses thereof. The invention also provides an immunostimulatory peptide containing the amino acid sequence DPNAPKRPPSAFFLX1X2X3X4 or derivatives thereof. In one embodiment, when X1 is alanine (A), glycine (G), or valine (V) then X2 is C, X3 is S and X4 is E; wherein when X2 is alanine (A), glycine (G), or valine (V) then X1 is F, X3 is S and X4 is E; wherein when X3 is alanine (A), glycine (G), or valine (V) then X1 is F, X2 is C and X4 is E; or wherein when X4 is alanine (A), glycine (G), or valine (V) then X1 is F, X2 is C and X3 is S.
Claims11
An immunostimulatory peptide consisting of the amino acid sequence SAFFLFCSE (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.