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US 9,539,318 B2Granted
Allergen desensitization method
AssigneeDBV Technologies
InventorsChristophe Dupont, Pierre-Henri Benhamou, Bertrand Dupont
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Abstract
The present application relates to a method for desensitization of allergic patients. More specifically it relates to an epicutaneous desensitization method, applicable to any type of allergens and of patients. The method of the invention is essentially non-invasive and does not require the use of adjuvants. Further, it may be easily applied and monitored by the actual patient.
Claims14
A method for epicutaneous desensitization of a subject allergic to an allergen, the method comprising:
- a) determining a dose of the allergen which causes a local inflammatory reaction on the skin of the subject upon epicutaneous application thereof;
- b) epicutaneously exposing the subject to the allergen and generating the local inflammatory reaction in the subject by applying said dose of the allergen, without an adjuvant, on to an intact region of skin of the subject;
- and
- c) repeatedly applying the allergen, without an adjuvant, to an intact region of the skin of the subject, at a dose, frequency or for an application time adapted to sustain a local inflammatory reaction, the exposure and sustained reaction leading to desensitization of the subject;
- wherein the allergen is applied by means of a cutaneous occlusive device configured to ensure contact between the allergen and the region of skin, and wherein said dose of allergen is comprised between 0.1 and 1,000 μg/cm2 of a surface area of the device.
2 more elements
Dependencies are inferred from the claim text.