US 9,539,314 B2 · Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis

Abstract

Provided are methods of enhancing an immune response and methods for reducing the recruitment of monocytes to a lymph node by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an antigen. The invention also provides relate methods for amplifying vaccine immunity by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an vaccine. The invention also provides related methods of inhibiting tumor growth and metastasis by administering to an individual with cancer an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an anti-tumor preparation. In addition, related compositions comprising an ARB or a compound of Formula (I) and an antigen, vaccine, or anti-tumor preparation are provided.

Claims16

Dependent claims

A method of amplifying vaccine immunity in an individual, the method comprising administering to the individual the vaccine in conjunction with an effective amount of a compound of Formula (I):

wherein
R1 is hydrogen or C1-6alkyl;
is a single bond or double bond;
Q1 is N or CH;
R2 is selected from hydrogen and C1-6 alkylene, wherein one carbon unit of said alkylene is optionally replaced with —O—, —S—, —SO—, —SO2—, —NRa—, or —CO—;
wherein Ra is hydrogen or C1-6 alkyl;
and
R3 is hydrogen or an optionally substituted 5-membered heteroaryl ring;
wherein the heteroaryl ring is optionally substituted with C1-6alkyl;
or pharmaceutically acceptable salts thereof.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/609,146Filed 29 Jan 2015 · division

Priority

1 Mar 2013

Published

US 2015/0182608 A12 Jul 2015

Granted

10 Jan 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 39/0005
Medicinal preparations containing antigens or antibodies: vertebrate antigens
A61K 31/404
Condensed with carbocyclic rings, e.g. carbazole: indoles, e.g. pindolol
A61K 31/4178
1,3-Diazoles: not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A61K 31/437
Ortho- or peri-condensed with heterocyclic ring systems: the heterocyclic ring system containing a five-membered ring having nitrogen as a ring…

Family

Application61/771,738Us provisional application · filed 1 Mar 2013

Application61/771,744Us provisional application · filed 1 Mar 2013

Application14/195,688Parent of this division · filed 3 Mar 2014

US 2015/0182608 A1Pre-grant publication · published 2 Jul 2015

US 8,975,290 B2Parent of this division

US 2014/0248315 A1Published application

US 9,539,314 B2This patent

From the US filing history. Foreign family members aren’t listed.

Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis

Life of this patent

Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis

Life of this patent

Abstract

Claims16