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AssigneeUniversidad Nacional Autonoma De Mexico
InventorsJaime Mas Oliva, Blanca Alicia Delgado Coello, Victor Guadalupe García Gonzalez, Armando Perez Torres
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The present invention provides a novel vaccine compound of micellar nanoparticles to be administered intranasally to treat and/or prevent the disease called atherosclerosis, which results from an abnormal metabolism of circulating lipids. The novelty of the vaccine compound of the present invention is the use of Archaebacterian lipids, lysophosphatidylcholine, and phosphatidylcholine, which give nanoparticles stability and facilitates antigen presentation in its appropriate secondary peptidic conformation. A novel process for the preparation of vaccine compounds which allows obtaining homogeneous nanoparticles with high stability is also presented in this invention.
A vaccine composition of micellar nanoparticles for intranasal administration comprising a carboxyl terminus peptide of a cholesteryl ester transfer protein (CETP) set forth as SEQ ID NO:
A vaccine composition of micellar nanoparticles for intranasal administration comprising:
A process for preparing a vaccine composition of micellar nanoparticles to be administered intranasally comprising:
Dependencies are inferred from the claim text.