Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
AssigneeFleurir Abx LLC
InventorJohn Lee Pace
Life of this patent
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Abstract
New improved formulations comprising a first composition and a second composition, the first composition being a streptogramin, the second composition being an inhibitor of lipid A deacetylase resulting in permeabilization of an outer membrane of a microorganism to which it is provided to. Said composition, alone or in combination may be used to treat bacterial infections, providing better efficacy, bioavailability and or pharmacokinetics as compared with other antimicrobial agents. The combination may be provided independently or together, and via any route(s) and in any formulation or form.
Claims24
A composition comprising a combination of a first composition and a second composition, the first composition being a streptogramin, and the second composition being a compound effective in permeabilizing an outer membrane of a susceptible microorganism, the susceptible microorganism being one or more of a Gram positive bacteria and a Gram negative bacteria, the compound being a compound of formula I:
- wherein R3 is any one of:
- and wherein R1 is any one of:
A composition comprising an inhibitor of an enzyme involved in lipid A biosynthesis in a susceptible microorganism, the inhibitor resulting in permeabilization of an outer membrane of the susceptible microorganism to which the inhibitor is provided in order to subsequently or concomitantly introduce a streptogramin to the susceptible microorganism, the susceptible microorganism being one or more of a Gram positive bacteria and a Gram negative bacteria, wherein the inhibitor is a compound of formula I:
- wherein R3 is any one of:
- and wherein R1 is any one of:
Dependencies are inferred from the claim text.