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US 9,539,303 B2Granted
Treatment of Ras-expressing tumors
AssigneeCelgene Corporation
InventorsWilliam McCulloch, Mitchell Keegan
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Abstract
The present invention provides compositions and methods for the treatment of /?αs-expressing tumors using at least one DAC inhibitor (e.g., romidepsin).
Claims15
A method of treating a Ras-expressing tumor comprising the steps of administering to a subject suffering from the Ras-expressing tumor:
- a) a therapeutically effective amount of romidepsin;
- and
- b) a therapeutically effective amount of gemcitabine;
- wherein the Ras-expressing tumor is a blood borne tumor selected from the group consisting of leukemia, multiple myeloma, and myelodysplastic syndrome.
1 more element
A method of treating a Ras-expressing tumor comprising the steps of administering to a subject suffering from the Ras-expressing tumor:
- a) a therapeutically effective amount of romidepsin;
- and
- b) a therapeutically effective amount of gemcitabine;
- wherein the Ras-expressing tumor is a solid tumor.
1 more element
Dependencies are inferred from the claim text.