Modulating disease through genetic engineering of plants
AssigneeThe Regents of the University of California
InventorsAlan M. Fogelman, Srinivasa T. Reddy, Mohamad Navab
Life of this patent
Estimating the term…
Abstract
In certain embodiments transgenic plants (e.g., transgenic tomatoes) are provided that comprise cells that express a peptide one or more domains of which comprise the amino acid sequence of an apolipoprotein or apolipoprotein mimetic peptide where the peptide has biological activity (e.g., lowers SAA, and/or increases paroxonase activity, and/or improves HDL inflammatory index, etc.) when the plant and/or the peptide is fed to a mammal.
Claims22
A transgenic tomato plant comprising cells that express a peptide one or more domains of which comprise the amino acid sequence DWLKAFYDKFFEKFKEFF (SEQ ID NO:
- 17) wherein said peptide in a fruit of said plant is effective to decrease plasma levels of lysophosphatidic acid (LPA) in a mammal, and/or to decrease serum amyloid A (SAA) levels in said mammal, and/or to increase plasma paraoxonase activity in said mammal when said fruit is fed to said mammal as a lyophilized powder.
Dependencies are inferred from the claim text.