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US 9,539,292 B2Granted
Compositions and methods for treatment of microbial infections
AssigneeImmunology Laboratories, Inc.
InventorsJiri Pillich, John C. Balcarek
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Abstract
The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an effective amount of bacterial lysate compositions for the treatment of pathological conditions of microbial infections. The present invention can also be used to enhance the immune system to prevent infections by the administration of an effective amount of the compositions.
Claims5
A method of preparing a bacterial lysate, wherein the bacterial lysate comprises,
- a) growing at least one bacterial strain in culture to a concentration that is at least 1×106 cells per milliliter, wherein the least one bacterial strain is a Staphylococcus aureus (S. aureus) strain deposited with the Czech Collection of Microorganisms (CCM) having accession number CCM 4995 or CCM 4997, or both strains CCM 4995 and CCM 4997;
- b) adding to the bacterial strain in culture sufficient amounts of at least one bacteriophage to yield a concentration of at least 1×108 phage particles per milliliter, wherein the at least one bacteriophage is a bacteriophage deposited with the Deutsche Sammlung von Mikroorganismen and Zellkulturen GmBH (DSM) having accession number DSM 14616;
- c) allowing infection and lysis to proceed from 3 to 48 hours;
- and
- d) sterilizing the lysate.
2 more elements
Dependencies are inferred from the claim text.